About Uveal Melanoma Symptoms and Metastatic Risk
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Today I treated a patient with uveal melanoma. Uveal melanoma arises from melanocytes in the uveal tract, most commonly the choroid. It features distinct molecular drivers, with nearly all cases harboring mutually exclusive activating mutations in GNAQ or GNA11, leading to aberrant signaling and tumor growth. Secondary alterations in BAP1, SF3B1, or EIF1AX promote progression and confer high metastatic potential, primarily hematogenous spread to the liver. Risk factors include light iris color,
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