Valproate is an epilepsy drug that can cause what is called Valproate Syndrome in children born to women using the drug. Sky’s Jason Farrell explains. 🔗 Link in bio to read more #Valproate #epilepsy #ValproateSyndrome | Sky News
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NHS England » Supporting the safety of girls and women being treated with valproate
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Aazer Nawab on Instagram: "Valproate-related hyperammonemic encephalopathy (VHE) is a serious but reversible complication of valproic acid therapy. A condition where serum ammonia rises due to valproate, leading to altered mental status, even when LFTs are normal and valproate levels may be therapeutic. -Mechanism Valproate: •Inhibits carbamoyl phosphate synthetase-1 (CPS-1) → blocks urea cycle •Causes carnitine deficiency •Produces toxic metabolites such as 4-en-VPA •Leads to accumulation of am
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