Cold Tumors vs Hot Tumors: Why Immunotherapy Sometimes Fails Not all tumors are visible to the immune system. Cold tumors fall into two categories: • Immune desert – the immune system doesn’t recognize the tumor at all • Immune excluded – immune cells reach the tumor edge but are blocked from entering In both cases, T-cells can’t engage, which means immunotherapy struggles to work. So the real question becomes: 👉 How do we help convert cold tumors into hot ones? When reviewing repurposed anti-p
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