Drugs to be avoided in patients with long QT syndrome: Focus on …
Though the effects of fentanyl on QTc interval are conflicting, fentanyl and morphine have been used in patients with c-LQTS without any adverse effect[17,33-36].
Opioids and Cardiac Arrhythmia: A Literature Review - PMC
Chang et al. demonstrated that at clinical doses (2 μg/kg), fentanyl not only does not prolong QT and QTc interval but also diminishes the prolongation of QT interval if used before laryngoscopy and tracheal intubation during propofol induction.
Effects of fentanyl pretreatment on the QTc interval during …
The aim of this study was to investigate the effects of fentanyl on the QTc interval during propofol induction in healthy patients. The patients were randomly allocated to receive either fentanyl (n = 25) or saline (n = 25) before induction.
Opioids-Induced Long QT Syndrome: A Challenge to Cardiac Health
In addition to methadone and LAAM, both fentanyl and orlistat have now been validated in cytologic experiments for possible inhibition of hERG channels, prolongation of the QTc interval, and increased susceptibility to sudden cardiac death . Many drugs have been shown to inhibit hERG channel function.
Effects of fentanyl pretreatment on the QTc interval during …
Sep 5, 2008 · Fourteen control subjects and seven patients in the fentanyl group developed a QTc prolongation exceeding 20 ms from baseline following intubation, which shows the attenuating effect of fentanyl on the QTc prolongation during propofol induction.
Does IV fentanyl, frequently used in emergency departments, change QT
Sep 4, 2024 · Our study found that fentanyl affected the QT C value and prolonged the QT C at the highest 30th minute (median 13.08 ms). In our study, patients with drug use affecting the QT C value were excluded, and no other agent was administered to the patients before or during fentanyl administration.
Effects of Fentanyl Versus Remifentanil Pretreatment on the QTc ...
Nov 25, 2022 · One of the complications of laryngoscopy is cardiac dysrhythmia due to an increased QT interval. This study aimed to compare the effect of fentanyl and remifentanil on QTc interval in patients undergoing intubation by the rapid method in 2020.
Does IV fentanyl, frequently used in emergency departments, change QT
Sep 4, 2024 · Fentanyl prolonged the QT<sub>C</sub> value statistically significantly. Although no patient developed malignant arrhythmia clinically, our results suggest that this QT<sub>C</sub>-prolonging effect should be considered …
Drug-Induced QT Prolongation - U.S. Pharmacist
Feb 20, 2007 · Several drugs have been withdrawn from the U.S. market or have received black box warnings due to their potential to cause QT interval prolongation that leads to fatal ventricular arrhythmias and sudden cardiac death. 1,2 Predicting the risks involved with most of these drugs is difficult, since they are often structurally and pharmacologically ...
Drug-Induced QTc Interval Prolongation: A Multicenter Study to ... - PubMed
Results: Among patients, 9.9% presented QTc >450/470 ms, 3% QTc > 500 ms, 12.7% ΔQTc >30 ms and 5.2% ΔQTc >60 ms. QTc prolongation associated with congestive heart failure, ischemic cardiopathy, diabetes, renal failure, arrhythmias, hypothyroidism, and bradycardia.