Watch Matt Maiocco’s full interview with Kyle Shanahan on “49ers Game Plan,” airing Wednesday at 9 p.m. PT on NBC ...

San Francisco 49ers defensive tackle Alfred Collins out for the year after suffering a torn patellar tendon during a practice ...

Kyle Shanahan reveals the 49ers' keys to beating the Rams and discusses Mike Evans, De'Zhaun Stribling and Deebo Samuel ahead ...

San Francisco 49ers fans who were looking forward to enjoying a version of their last Super Bowl team have endured some drama ...

The 49ers and Rams released their latest injury reports ahead of Thursday's Week 1 matchup in Australia, with nine San ...

The Rams have arrived in Australia ahead of their Week 1 matchup with the 49ers. See why Los Angeles took a different approach to the trip than San Francisco.

The tape and the numbers have always backed Brock Purdy. Now San Francisco's signal-caller is primed to shed the "Mr.

QB Brock Purdy landed at No. 15 in Nick Shook's NFL rankings. See where he ranks among the league's best and why his Tier 3 ...

Can Drake Maye and the Patriots avenge a humbling Super Bowl LX loss to the Seahawks in tonight's NFL Kickoff Game? Will the ...

The 49ers surprisingly took a running back in the third round of the draft, and at least one analyst expects him to have a ...

Edge rusher Nick Bosa is set to return in the 49ers’ season opener against the Los Angeles Rams, and linebacker Dre ...

The 49ers asked the NFL for a Monday night Week 2 game after opening the season in Australia. Kyle Shanahan revealed the ...