According to DraftKings, Duke (+110) has the best odds to win the title entering the Final Four. Florida (+250), Houston (+400) and Auburn (+475) round out the rest of the Final Four teams. Gambling problem? Call (877-8-HOPENY) or text HOPENY (467369).

By bypassing the Blue Devils for the title, you can differentiate your entry. Duke’s prowess has made it the most popular title pick in ESPN’s bracket contest ( 25 percent of entries as of Tuesday) as well as CBS’s. Not going with Duke to win is a smart pool strategy Mock outlines here — while still collecting points by riding Duke to the finals.

SportsLine's model revealed its college basketball predictions for Michigan Wolverines vs. Auburn Tigers on Friday in the Sweet 16 of the 2025 NCAA Tournament