We have adapted the dock-and-lock (DNL) method into a novel PEGylation technology using human interferon-α2b (IFN-α2b) as an example. Central to DNL is a pair of distinct protein domains involved in ...

Objective To examine the long-term impact of early treatment initiation of interferon beta-1b (IFNB1b, Betaferon/Betaseron) in patients with a first event suggestive of multiple sclerosis (MS).

They then validated their results in a further 73 children with JIA. The researchers focused on a group of genes involved in the interferon pathway, which helps to control the immune system.

Interferons are circulating factors that bind to cell surface receptors, activating a signaling cascade, ultimately leading to both an antiviral response and an induction of growth inhibitory and ...

Purpose TLR7 and TLR8 (TLR7/8) are members of the Toll-Like Receptor family that recognize single strand RNA. Activation of TLR7/8 within immune cells elevates pro-inflammatory cytokines and type ...

Keywords: anti-interferon- γ autoantibody positivity, adult-onset immunodeficiency syndrome, non-typhoidal Salmonella, extraintestinal dissemination, diagnostic and therapeutic thinking Citation: Shao ...