IFIT3, a key effector molecule in the interferon signaling pathway, not only amplifies IFN-mediated antiviral responses but also modulates TLR signaling by interacting with key adaptor proteins such ...

At the core of this pathway is cGAS-dependent production of the intra- and extra-cellular messenger cGAMP, which activates STING and leads to IRF3-dependent expression of cytokines and interferons.

This month's cover highlights the article RudLOV is an optically synchronized cargo transport method revealing unexpected effects of dynasore by Akiko K. Satoh, Takunori Satoh and colleagues. The ...

This study provides important insights into the regulation of type-I interferon signaling and anti-tumor immunity, demonstrating that ORMDL3 promotes RIG-I degradation to suppress immune responses.

The interferon (IFN) family of proteins plays key roles in the immune response against viruses and other pathogens. In the context of COVID-19, IFNs have been shown to be key for restraining ...

For instance, there are a variety of proteins that inhibit the activation of the transcription factors interferon regulatory factor 3 (IRF3) and nuclear factor kappa B (NF-κB) or the Janus kinase (JAK ...

We hypothesized that responses to complex combinations of ligands displayed by different classes of bacterial pathogens may reflect the operation of interacting feedback controls evoked by engagement ...