Maintaining high transcriptional fidelity is essential to life. For all eukaryotic organisms, RNA polymerase II (Pol II) is responsible for messenger RNA synthesis from the DNA template. Three key ...

The design of miRNA viral vectors is relatively simple. miRNAs are transcribed by RNA polymerase II, and their primary transcripts contain a 5' cap and poly (A) tail. [136] ...

Laiho holds patents on RNA polymerase 1 inhibitors, which are managed by The Johns Hopkins University in accordance with its conflict-of-interest policies.

This patent describes a novel therapeutic strategy involving conjugate compounds that integrate a poly(ADP-ribose) polymerase (PARP) inhibitor moiety with a disease-targeting ligand, offering a ...