Laiho holds patents on RNA polymerase 1 inhibitors, which are managed by The Johns Hopkins University in accordance with its conflict-of-interest policies.

About Resolve Therapeutics Resolve is a biopharmaceutical company at the forefront of the emerging field of cell-free nucleic acids in disease. We are developing RSLV-132 and RSLV-145 in a broad range ...

Poly adenosine diphosphate-ribose polymerase (PARP) inhibitors, a class of targeted anticancer therapies, prevent genetic repair mechanisms in cancer cells by competitively binding to the active ...

Now, researchers used cryoelectron microscopy (cryo-EM) to elucidate the structure of the Nipah virus polymerase complex (the large protein and phosphoprotein).

As mRNA therapeutics expand into cancer vaccines, cell therapies and beyond, manufacturing high-quality mRNA with minimal byproducts is more critical than ever. This poster explores how a novel ...

In addition to its newly launched CleanScribe RNA Polymerase, TriLink offers mRNA capping analogs (including the award-winning CleanCap® M6), mRNA raw materials (nucleotides and other IVT enzymes ...

Zhu has now taken a significant step towards that goal by creating three crucial mirror RNA strands that will form the structural and catalytic core of a mirror ribosome, making up about two ...

This allows them to be inserted into the nascent RNA. Remdesivir (RDV) was developed to fight the Ebola virus back in 2014 but was repurposed against the current coronavirus disease 2019 (COVID-19).

Compared to the Pfizer/BioNTech and the Moderna mRNA vaccines, which use 30 and 100 micrograms, respectively, a recently tested self-amplifying RNA vaccine used only 0.1-10 micrograms — this ...

In 2020, ASCO published a guideline on poly (ADP-ribose) polymerase inhibitor (PARPi) therapy in the management of ovarian cancer. 1 In June 2022, the ATHENA-MONO 2 phase III multinational, ...

Poly (ADP-Ribose) Polymerase Inhibitors in the Management of Ovarian Cancer: ASCO Guideline Rapid Recommendation Update The following represents disclosure information provided by authors of this ...