In 2001, imatinib was the first proof that small molecule inhibitors targeting molecular drivers of cancer could be an ...

This important study identifies and characterizes a set of amino acid states that can rescue protein function in the presence of substantially deleterious mutations. Some of these super-compensatory ...

The “multi-omics” approach combines several kinds of biological information, including DNA, RNA activity, and the epigenome, ...

Nearly every cell in the human body contains essentially the same genetic information, yet different cells activate different ...

Atrial fibrillation (AFib) occurs when chaotic electrical signals cause the heart’s upper chambers to beat irregularly and ...

Scientists have long believed that disease-causing genetic variants inevitably lead to disease. But a sea change of research ...

When a wound does not heal properly, it leaves a scar. Similarly, mutations—which are permanent changes to genetic code—are often the result of damaged DNA that has not been properly repaired.