High levels of fat mass and obesity-associated protein (FTO) have been linked to increased tumor growth and resistance to ...

Merck Sharp & Dohme LLC patents report the development of proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase (Von Hippel-Lindau disease tumor suppressor [VHL] ligands) ...

High levels of fat mass and obesity-associated protein (FTO) have been linked to increased tumor growth and resistance to ...

As U-box domains typically function to bind ubiquitin ... an E3-independent substrate of UBCH5A in vitro. The authors should state this possibility more clearly and avoid terminology such as ...

We determine the crystal structure of the C-terminal part of IFT172, uncovering a conserved U-box-like domain often found in E3 ubiquitin ligases. This domain exhibits ubiquitin-binding properties and ...

When encountering cellular stress, E3 ligases must deal with proteins that have been damaged in many different ways. For example, misfolding can expose multiple hydrophobic regions in the same ...

Multiple sclerosis (MS) is one of the most widespread disabling neurological conditions of young adults around the world. It affects almost 1 million people in the United States, and about 2.9 ...

He previously worked at Android Police and Tech Advisor. Google’s AI assistant Gemini is now able to carry out tasks across multiple apps in a single interaction, in an update announced today ...

Powered by a 9.2 kWh battery, it features three driving modes and TVS SmartXonnect™ technology for real-time navigation and diagnostics. TVS launches e3-wheeler, priced at Rs 2.95 lakh.