Multiple sclerosis (MS) is one of the most widespread disabling neurological conditions of young adults around the world. It affects almost 1 million people in the United States, and about 2.9 ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

He previously worked at Android Police and Tech Advisor. Google’s AI assistant Gemini is now able to carry out tasks across multiple apps in a single interaction, in an update announced today ...

Powered by a 9.2 kWh battery, it features three driving modes and TVS SmartXonnect™ technology for real-time navigation and diagnostics. TVS launches e3-wheeler, priced at Rs 2.95 lakh.

Here, we have applied immunoprecipitation followed by tandem mass spectrometry using the autophagosome marker protein ATG8 as bait and have identified the E3 ligase of the ufmylation system Ufl1 as a ...

Importantly, AUCell analysis revealed that CHIP E3 ubiquitin ligase activity deficiency affected ubiquitin-mediated proteolysis, ultimately increasing the level of intracellular cAMP. The activation ...

Fluorescence intensity measurements were used to monitor the cleavage of a ubiquitin-rhodamine substrate. All activity assays were performed in black 384-well plates in assay buffer (20 mM Tris–HCl, ...

However, comprehensive, DUB profiling, across multiple classes, remains to be carried out. MALDI-TOF–based methodology for profiling DUB isopeptidase/esterase activity. (A) DUBs are incubated either ...