Kangpu Biopharma receives China NMPA’s IND approval for KPG-818 to treat relapsed/refractory multiple myeloma: Hefei, China Saturday, March 1, 2025, 14:00 Hrs [IST] Kangpu Bioph ...

KPG-818 is a novel oral molecular glue modulator of the E3 ubiquitin ligase complex CRL4-CRBN. It demonstrated high cereblon (CRBN) binding affinity and potent degradation of Aiolos (IKZF3) and Ikaros ...

IND approval record on CDE official website KPG-818 is a novel oral molecular glue modulator of the E3 ubiquitin ligase complex CRL4-CRBN. It demonstrated high cereblon (CRBN) binding affinity and ...

For example, DELTEX E3 ligases were reported to ubiquitylate a hydroxyl group on free NAD + and ADP-ribose in vitro, generating a noncanonical ubiquitin ester-linked species. In this report, we show, ...

Huang Ying from Xinhua Hospital, Shanghai Jiaotong University School of Medicine, expressed and purified the SPO11-TOP6BL complex using Expi293F cells. They demonstrated that this complex cleaves ...

The review article explores recent advances in human tissue-derived immune organoid culture systems that replicate complex immune cell dynamics ex vivo. These versatile experimental platforms enable ...

Since the degradation of most proteins is mediated by E3 ubiquitin ligases, the team further investigated and identified DTX2 as the E3 ubiquitin ligase involved in VES-mediated FTO degradation.

Dysregulation of the E3-ubiquitin ligase RNF146-mediated degradation of the adaptor ... resulting in the formation of a protein complex and transference of the activated ubiquitin from E2 to the ...

The ubiquitin-proteasome system comprises three types of enzymes ... 2004). Only if it forms an E3 ligase complex with Cul3 and Roc1 can it induce the ubiquitination of its substrates like PML and ...

Drugs that hijack ubiquitin ligases to tag disease-causing proteins have been ... that E2 and E3 concentrations in cells may be insufficient to saturate the E3–substrate complex, resulting in slower ...