A degrader molecule, either PROTAC or molecular glue, brings the protein of interest (POI) and E3 ubiquitin ligase in close proximity and engages ... while Bcl-2 lacks such an accessible lysine, which ...

that targets lysine-specific demethylase 1 (LSD1 or KDM1A), an enzyme crucial for cancer stem and progenitor cells, particularly in abnormal bone marrow cells. Bomedemstat is currently being ...

investigated the role of the E3 ubiquitin ligase ITCH in the life cycle of SARS ... ubiquitination of E and M impacts virus assembly and release. Identifying the specific lysine residues in M and E ...

It is “a good first step to start looking at the specific genes” that may affect speech and language development, said Liza Finestack at the US-based University of Minnesota, who was not ...

NOVA1 may be a bona fide human 'language gene,' though certainly it's only one of many human-specific genetic changes." Robert B. Darnell, head of the Laboratory of Molecular Neuro-Oncology ...

A lot of HP users are unable to print documents as the error code E3 pops up every time they try to do the same. In this article, we are going to see what you should ...

Dysregulation of the E3-ubiquitin ligase RNF146-mediated degradation of the adaptor protein 3BP2 (SH3 domain-binding protein 2) causes cherubism, an autosomal dominant disorder associated with severe ...

In combination with UBE2R1/2, the E2 UBE2D3 and the E3 ARIH1 both promoted SCF-mediated polyubiquitylation in a substrate-specific fashion ... substrates p27 and CYCLIN E as well as the CUL2-RING ...