that targets lysine-specific demethylase 1 (LSD1 or KDM1A), an enzyme crucial for cancer stem and progenitor cells, particularly in abnormal bone marrow cells. Bomedemstat is currently being ...

investigated the role of the E3 ubiquitin ligase ITCH in the life cycle of SARS ... ubiquitination of E and M impacts virus assembly and release. Identifying the specific lysine residues in M and E ...

E3 ligase links ubiquitin to specific substrates, allowing ubiquitinated proteins ... Mechanistic studies indicate that RNF5 binds to the transmembrane domain of SCAP and ubiquitinates lysine 305 ...

Dysregulation of the E3-ubiquitin ligase RNF146-mediated degradation of the adaptor protein 3BP2 (SH3 domain-binding protein 2) causes cherubism, an autosomal dominant disorder associated with severe ...

In combination with UBE2R1/2, the E2 UBE2D3 and the E3 ARIH1 both promoted SCF-mediated polyubiquitylation in a substrate-specific fashion ... substrates p27 and CYCLIN E as well as the CUL2-RING ...