Leveraging a novel protein tagging strategy offers new route to cancer treatment
In a pioneering collaboration with AbbVie, Northwestern researchers have discovered a new way to potentially treat cancer by ...
Nature1mon
Mdm2–SUMO1: is bigger better?
Covalent modification of the oncogene product Mdm2 by the ubiquitin-related protein SUMO1 protects it from ubiquitination and enhances its E3 ligase activity towards p53 in vitro. Disappearance of ...
Medscape1mon
Activity-based profiling of cullin-RING E3 networks by conformation-specific probes.
The cullin-RING ubiquitin ligase (CRL) network comprises over 300 unique complexes that switch from inactive to activated conformations upon site-specific cullin modification by the ubiquitin-like ...
mskcc.org6y
Post-Translational Protein Modification by Ubiquitin-like Proteins
One early study revealed the kinetic basis for E3 ligase domains within the Nup358/RanBP2 nucleoporin ... that were required for specific recognition of SUMO-PCNA in vitro and in vivo. Ongoing studies ...