BioWorld2d
Merck Sharp & Dohme prepares new KRAS G12D degrader PROTACs
Merck Sharp & Dohme LLC patents report the development of proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase (Von Hippel-Lindau disease tumor suppressor [VHL] ligands) ...
eLife14d
Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling
We determine the crystal structure of the C-terminal part of IFT172, uncovering a conserved U-box-like domain often found in E3 ubiquitin ligases. This domain exhibits ubiquitin-binding properties and ...
Frontiers24d
Transcriptional survey of the light-induced anthocyanin pathway in non-GM purple tomatoes
PlantLab, Institute of Plant Sciences, Scuola Superiore Sant’Anna, Pisa, Italy Anthocyanins are polyphenolic compounds with antioxidant capacity, free radical scavenging power, and signaling ...