C&EN

Arginine ADP-Ribosylation: Chemical Synthesis of Post-Translationally Modified Ubiquitin Proteins

Oncode Institute and Department of Cell and Chemical Biology, Leiden University Medical Centre, Einthovenweg 20, 2333 ZC Leiden, The Netherlands ...
IEEE

Deep-USIpred: identifying substrates of ubiquitin protein ligases E3 and deubiquitinases with pretrained protein embedding and bayesian neural network

Abstract: Identifying the substrates of ubiquitin protein ligase (E3) and deubiquitinases (DUB) contributes to the discovery of potential therapeutic targets for diseases. However, experimental ...
EMBO Press

Neuralized-like proteins differentially activate Notch ligand

The NEURL E3 ubiquitin ligases selectively activate the Notch ligands DLL1 and JAG1, but not DLL4 and JAG2. This differential ...
IGN

E3 Has Been Canceled

Almost a year after announcing its return, the Entertainment Software Association announced today to its members that this year's Electronic Entertainment Expo (E3), has been canceled, IGN can confirm ...
Frontiers

The role of ubiquitin ligases in regulating immune cell functions

Department of Medicine, School of Medicine, Stanford University, Palo Alto, CA, United States Regulatory T cells (Tregs) play a central role in immune homeostasis and the preservation of immunological ...