The NEURL E3 ubiquitin ligases selectively activate the Notch ligands DLL1 and JAG1, but not DLL4 and JAG2. This differential ...

Almost a year after announcing its return, the Entertainment Software Association announced today to its members that this year's Electronic Entertainment Expo (E3), has been canceled, IGN can confirm ...

BOSTON and SOUTH SAN FRANCISCO, Calif., Oct. 03, 2025 (GLOBE NEWSWIRE) -- Frontier Medicines Corporation, a clinical-stage precision medicine company unlocking the proteome to develop small molecule ...

Jake has been an automotive journalist since 2015, joining CAR as Staff Writer in 2017. With a decade of car news and reviews writing under his belt, he became CAR's Deputy News Editor in 2020 and ...

Traditional drug research has focused on creating inhibitors that occupy the active areas of disease-related proteins, preventing them from functioning properly. But this strategy leaves a ...

Xbox has stopped development of Contrabrand to "evaluate the project's future," with a Bloomberg report saying the game is canceled entirely four years after its initial E3 announcement. Bloomberg ...

The study describes a valuable new technology in the field of targeted protein degradation that allows identification of E3-ubiquitin ligases that target a protein of interest. The presented data are ...

Recently, many people have been asking me to recommend an ergonomic office chair that is both affordable and highly comfortable. After extensive research, I discovered a chair that stands out due to ...

Clearance of damaged mitochondria via mitophagy is crucial for cellular homeostasis. Apart from Parkin, little is known about additional Ub (ubiquitin) ligases that mediate mitochondrial ...

1 Department of Hematology and Oncology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China 2 Department of Pharmacology, Yale Medical School, New Haven, CT, United States ...

E3 is finished, for good this time. The Entertainment Software Association confirmed today that the event will not be happening in 2024 or any time thereafter, bringing 28 years of the video game ...