In this study, we report that the PEA3 group members interact with the mammalian really interesting new gene (RING) E3 ubiquitin ligase constitutive photomorphogenetic 1 (COP1), which mediates ...

In this study, we identify mammalian constitutive photomorphogenic 1 (COP1) as a novel E3 ubiquitin ligase for targeting 14-3-3σ through proteasomal degradation.

The Constitutive Photomorphogenesis 1 (COP1)protein is an ubiquitin E3 ligase, which targets many proteins for degradation. Until now, it has been most extensively studied for its role in repression ...

Here it is reported that mice with a mutant form of the E3 ubiquitin ligase ITCH display reduced litter sizes due to a maternal effect. Mutant females had decreased numbers of implantations, corpa ...

Role of Ubiquitin Ligases and the Proteasome in Oncogenesis: Novel Targets for Anticancer Therapies. JCO 31 , 1231-1238 (2013). DOI: 10.1200/JCO.2012.44.0958 ...

According to Trejo, a handful of drugs that inhibit E3 ubiquitin ligases have been approved by the Food and Drug Administration (FDA) for the treatment of some cancers, including multiple myeloma ...

In this webinar, brought to you by Bio-Techne, Jennifer Johnston will discuss how her research of ubiquitin-proteasome system elements, including Parkin E3 ligase, is used to diagnose and treat ...

Deregulation of enzymes that control lipid turnover such as adipose triglyceride lipase (ATGL) is an essential contributor to nonalcoholic fatty liver disease. Recent studies suggest that a fraction ...

TRAF6 is a non-conventional E3 ubiquitin ligase with a unique receptor binding specificity. This protein comprises an N-terminal RING domain, multiple zinc finger motifs, and a C-terminal TRAF domain.

Apple E3 ligase MdPUB23 mediates ubiquitin-dependent degradation of MdABI5 to delay ABA-triggered leaf senescence. Article Publication Date. 30-Jan-2024. COI Statement.

Newco Outrun Therapeutics Ltd. has raised $10 million in a seed round to develop small-molecule E3 ubiquitin ligase inhibitors that prevent programmed protein degradation. The lead program targeting ...