The NEURL E3 ubiquitin ligases selectively activate the Notch ligands DLL1 and JAG1, but not DLL4 and JAG2. This differential ...

A new study has identified TRIM56, an E3 ubiquitin ligase, as a key activator of the proto-oncogene Src in hepatocellular carcinoma.

Thymus is the key organ for development and maturation of T lymphocytes. The dysfunction of thymus leads to decreased immunity or autoimmune diseases. T cells can be divided intoαβ T cells and γδ T ...

The poster, titled Translational Insights from a First-in-Human Study of an Oral CBL-B Inhibitor in Advanced Solid Tumors, expands upon data presented at the recent European Society for Medical ...

The first-of-its-kind study shows that adding a small molecule that blocks the problematic protein to existing cancer ...

Melanoma, the deadliest form of skin cancer, can't always be removed with a scalpel.Patients with advanced stages of melanoma ...

Beijing Innocare Pharma Tech Co. Ltd. has synthesized E3 ubiquitin-protein ligase CBL-B (CBLB) inhibitors reported to be useful for the treatment of cancer.

Research in the field of ubiquitination has unveiled it as a fundamental post-translational modification mechanism that meticulously directs protein fate ...

Haisco Pharmaceutical Group Co. Ltd. has synthesized proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to an EGFR (HER1; ...

Fertility: Research suggests p53 may play a role in female fertility and reproductive health. Therefore, p53 is a crucial ...