TLR4 signals via MyD88 and TRIF to activate proinflammatory cytokine and type I interferon responses. Karin and colleagues show that different ubiquitination of TRAF3 via K48 or K63 dictates the ...

Disruption of endocytosis abolished the TRAM–TRIF-dependent phosphorylation of interferon-regulatory factor 3 (IRF3), a component of the pathway that leads to the production of type I ...

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes. Cell Death & Differentiation , 2018; DOI: 10.1038/s41418-018 ...

Researchers have discovered that the interferon gamma receptor (IFNgR) signaling pathway is critical for susceptibility of glioblastoma tumors to killing by CAR T-cell immunotherapy.