Introduction: Sepsis, a life-threatening condition arising from an uncontrolled immune response to infection, can lead to organ dysfunction, with severe inflammation potentially causing multiple organ ...
Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada. (A.A.d.O., F.S., M.E.G., R.K., A.Q., C.-L.M.C., S.T.D.) Women and Children’s ...
Once activated by ligands on the cell surface, the TLR4/MD2 complex engage two separate downstream signaling pathways: the MyD88-dependent pathway and the TRIF-dependent pathway. The MyD88-dependent ...
Stimulation beyond a TLR4 threshold and Gram-negative bacteria-induced responses ... reflect the operation of interacting feedback controls evoked by engagement of the MyD88 and/or TRIF pathways. By ...
Innate immunity is the first immunological defence against pathogens. During virus infection detection of nucleic acids is crucial for the inflammatory response. Here we identify DNA-dependent protein ...
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