Laiho holds patents on RNA polymerase 1 inhibitors, which are managed by The Johns Hopkins University in accordance with its conflict-of-interest policies.

This study reveals that RNA polymerase I uses a unique stalling mechanism at abasic DNA sites, distinct from RNA polymerase II. Pol I’s tendency to stall prevents the production of defective ...

Avs’ Cale Makar wins James Norris Memorial Trophy by: Jacob Factor Posted: Jun 11, 2025 / 09:50 AM MDT Updated: Jun 11, 2025 / 03:14 PM MDT ...

RNA (ribonucleic acid) is a nucleic acid polymer where the carbohydrate is ribose. RNA is generally single-stranded, as DNA is transcribed by RNA polymerases into mRNA (messenger RNA), which is ...

RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns, splicing ...

The design of miRNA viral vectors is relatively simple. miRNAs are transcribed by RNA polymerase II, and their primary transcripts contain a 5' cap and poly (A) tail. [136] ...