Kangpu Biopharma receives China NMPA’s IND approval for KPG-818 to treat relapsed/refractory multiple myeloma: Hefei, China Saturday, March 1, 2025, 14:00 Hrs [IST] Kangpu Bioph ...

for KPG-818 for the treatment of relapsed/refractory multiple myeloma (RRMM). IND approval record on CDE official website KPG-818 is a novel oral molecular glue modulator of the E3 ubiquitin ligase ...

Multiple E3 ubiquitin ligases and deubiquitinating enzymes (DUBs) that regulate essential cancer-related proteins were identified. For instance, the study outlines the role of MDM2, an E3 ...

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For example, DELTEX E3 ligases were reported to ubiquitylate a hydroxyl group on free NAD + and ADP-ribose in vitro, generating a noncanonical ubiquitin ester-linked ... we discovered that multiple ...

E3 ubiquitin ligase is the most abundant and specific molecule in the ... It is worth noting that a single enzyme may target multiple proteins, and conversely, a single protein target may be regulated ...

This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), shedding light on potential therapeutic targets for combating tumor progression, ...

In a study published in Nature, researchers report the successful in vitro reconstitution of meiotic DNA double-strand breaks (DSBs) formation. Meiosis, a specialized form of cell division in most ...