In a pioneering collaboration with AbbVie, Northwestern researchers have discovered a new way to potentially treat cancer by ...
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Study identifies vitamin E succinate as key to tumor growth controlHigh levels of fat mass and obesity-associated protein (FTO) have been linked to increased tumor growth and resistance to ...
High levels of fat mass and obesity-associated protein (FTO) have been linked to increased tumor growth and resistance to ...
However, the power of PROTACs lies in the engagement of E3 ligases, and currently, less than two percent of the vast array of E3 ligases in the human genome have been explored in the TPD field. Dr.
Covalent modification of the oncogene product Mdm2 by the ubiquitin-related protein SUMO1 protects it from ubiquitination and enhances its E3 ligase activity towards p53 in vitro. Disappearance of ...
Merck Sharp & Dohme LLC patents report the development of proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase (Von Hippel-Lindau disease tumor suppressor [VHL] ligands) ...
In this study we have focused on the role of ubiquitin E3 ligase gene family of Arabidopsis in fungal susceptibility using Botrytis cinerea as model pathogen. Discovered genes will be available for ...
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