Kangpu Biopharma receives China NMPA’s IND approval for KPG-818 to treat relapsed/refractory multiple myeloma: Hefei, China Saturday, March 1, 2025, 14:00 Hrs [IST] Kangpu Bioph ...

IND approval record on CDE official website KPG-818 is a novel oral molecular glue modulator of the E3 ubiquitin ligase complex CRL4-CRBN. It demonstrated high cereblon (CRBN) binding affinity and ...

The tumor microenvironment is a complex ecosystem of tumor cells ... and metastasis. Multiple E3 ubiquitin ligases and deubiquitinating enzymes (DUBs) that regulate essential cancer-related ...

KPG-818 is a novel oral molecular glue modulator of the E3 ubiquitin ligase complex CRL4-CRBN. It demonstrated high cereblon (CRBN) binding affinity and potent degradation of Aiolos (IKZF3) and Ikaros ...

The effect of E3 ubiquitin ligase selection and cell type on the degradation profile ... The result is consistent with the finding that a productive ternary complex formation is required for targeted ...

itchy E3 ubiquitin protein ligase; MARCH3, membrane associated RING-CH 3; CHFR, checkpoint with forkhead-associated and RING finger domains; YAP, yes-associated protein; LUBAC, linear ubiquitin chain ...

This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), shedding light on potential therapeutic targets for combating tumor progression, ...

E3-ubiquitin ligase inducible degrader of the LDL receptor has a similar function to PCSK9 and is a potential therapeutic target. A desirable treatment target for HoFH patients is LDL-C ≤1.8 mmol/l.

This paper presents the important finding that BNIP3/NIX, a mitophagy receptor, and its binding to ATG18 are required for mitophagy during muscle cell reorganization in Drosophila. Although the ...