The study focuses on the mitochondrial E3 ubiquitin ligase MUL1, which plays an essential role in ... and an upregulation of Complex I subunits, which collectively mitigate the effects of HFD. This ...

E3-ubiquitin ligase inducible degrader of the LDL receptor has a similar function to PCSK9 and is a potential therapeutic target. A desirable treatment target for HoFH patients is LDL-C ≤1.8 mmol/l.

and attachment to the substrate protein by ubiquitin ligases (E3s). Macrophages play a key role in atherosclerosis through lipid uptake and inflammation. Here, the authors show that RNF128 ...

This paper presents the important finding that BNIP3/NIX, a mitophagy receptor, and its binding to ATG18 are required for mitophagy during muscle cell reorganization in Drosophila. Although the ...