Mechanically, we demonstrated that E3 ligase TNF receptor–associated factor 6 (TRAF6) participated in the ubiquitination of TBK1 in cGAS-STING signaling pathway. We showed that pA151R interacted with ...
receptor trafficking in the endosome, DNA damage responses and inflammatory pathways. Moreover, we describe defects in ubiquitin–UBD interactions that are relevant for the development of ...
USP44 deubiquitylates CDC20, a co-activator of the E3 ubiquitin ligase anaphase promoting complex or cyclosome (APC/C) that promotes the degradation of many key cell cycle regulators. USP44 ...
IRAK1 further activates the E3 ubiquitin ligase-TRAF6 to synthesize the K63-linked polyubiquitin chains, leading to the recruitment and activation of the TAK1 complex. The activated TAK1 further ...
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