Michael Rapé is in the Department of Molecular and Cell Biology ... can chemically modify proteins across their entire sequence. How E3 ligases deal with such diverse substrates, especially ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Although the substrates of many poxvirus E3 ubiquitin ligases ... acid F-box-like sequence. Through these two pathways, poxvirus CP77 inhibits NF-κB activation and weakens the signal transduction of ...

Chronic low-grade inflammation drives atherosclerosis and despite optimal pharmacological treatment of classical cardiovascular risk factors, one third of the ... mechanism of T-cell activation and ...

Research from Umeå University paves the way for a quantitative data analysis method to study the cell division process in ...

A method for genetically barcoding Drosophila is developed and used to tag defined cell populations in vivo for single-cell transcriptomics experiments and to enable multiplexed behavioral analysis.

A "pocket" on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct order. Two studies by researchers at the University of Konstanz investigated ...

Synthetic biologists from Yale were able to re-write the genetic code of an organism - a novel genomically recoded organism (GRO) with one stop codon - using a cellular platform that they developed ...

“By combining world-class research CAR-T cell therapy with indigenous manufacturing ... at their facility in Bengaluru and is priced at one-tenth the cost of a similar product in the US.

The end result of this approach? You're paying less per line each month than you would with a single line of the best cell phone plan overall. And that helps keep your monthly wireless bill ...