A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

HSC70 enables a rapid stress response by alternately regulating the activities of SCF ubiquitin ligase and COP9 signalosome (CSN) in a substrate-dependent manner. HSC70 enhances CSN deneddylation ...

Here, the authors show that aspirin impairs proteasomal activity, affecting the degradation of soluble proteins, and induces K63-linked ubiquitination to promote the clearance of insoluble protein ...