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Restoration of full length filamin C is sufficient to prevent FLNC deficient cardiomyopathy in mice

Filamin C (FLNC) is an essential cytoskeletal protein required for cardiomyocyte structural integrity and mechanotransduction. Truncating FLNC variants cause haploinsufficiency associated with dilated ...
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Astrocytic glutamate transporter loss drives chemoreflex hyperactivity and cardiorespiratory dysfunction in a heart failure model

Esteban Diaz-Jara, Sinay C. Vicencio, Katherin V. Pereyra, Karla G. Schwarz, Fernando C. Ortiz, Camilo Toledo, Ignacio Bernal-Santander, Sandeep Kaur, Bisan El Dakkak, Rodrigo Del Rio ...
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Impairing Golgin-45 transcription factor activity unleashes malignant secretion in lung cancer

Chao Wu, Abhishek Kumar, Shike Wang, Weina Zhao, Yuanxin Xi, Jing Wang, Abhinav K. Jain, William K. Russell, Hou-fu Guo, Xiaochao Tan, Jonathan M. Kurie ...
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FAP-targeting CAR T cells with constitutive IL-10 expression reduce kidney fibrosis in mice

Blake D. Jardin, Feiyan Liu, Li Li, Cheryl L. Smith, Jonathan A. Epstein ...
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Integrated hepatitis B virus DNA maintains surface antigen production during antiviral treatment

1 Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. 2 Department of Medicine, Johns Hopkins University School of Medicine, ...
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Ciliary localization of GPR75 promotes fat accumulation in mice

Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA. Address correspondence to: Peter K. Jackson, ...
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Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration

Chronic inflammation is a pathologic feature of neurodegeneration and aging; however, the mechanism regulating this process is not understood. Melatonin, an endogenous free radical scavenger ...
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Monocyte-derived pro-angiogenic ocular macrophages identified by spatial transcriptomics are essential for choroidal neovascularization

1 Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, United States of America 2 Institute for Vision Research, The University of Iowa, Iowa City, United States ...
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Targeting TET3 in macrophages provides a concept strategy for the treatment of endometriosis

Department of Obstetrics, Gynecology and Women’s Health, University of Missouri, Columbia, Missouri, USA. Address correspondence to: Jae-Wook Jeong, 1030 Hitt ...
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Metformin Preserves Regional Brain Glucose Uptake, Structure, and Functional Connectivity in Adults with Insulin Resistance

3 Department of Radiology, Mayo Clinic, Rochester, United States of America 4 Department of Quantitative Health Sciences, Mayo Clinic, Rochester, United States of America 5 Department of Psychiatry ...
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DNAJC30 biallelic mutations extend mitochondrial complex I–deficient phenotypes to include recessive Leber’s hereditary optic neuropathy

Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. Address correspondence to: Janey L. Wiggs, Harvard Medical School, Massachusetts Eye ...
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Corrigendum to Axon guidance cue SLIT2 regulates the murine skeletal stem cell niche through sympathetic innervation

Sympathetic tone is a central signaling axis inhibiting osteogenesis; however, the combination of durable local and systemic sympathetic effects on bone argues that multiple mechanisms, including ...