NF-κB is a dimeric transcription factor that consists of REL family members, including REL-A (also known as p65), c-REL, REL-B, p50 and p52 (ref. 14). p50 and p52 are derived from the larger ...
The ubiquitin/proteasome-dependent proteolytic pathway is an attractive target for therapeutics because of its critical involvement in cell cycle progression and antigen presentation. However, ...
Researchers from Harvard Medical School (HMS) have discovered how a protein called midnolin plays a key role in degrading many short-lived nuclear proteins. Their study showed that midnolin acts by ...
Influenza viruses are becoming increasingly resilient to medicines. For this reason, new active ingredients are needed. Important findings in this regard have been provided: for the virus to ...
A new study has identified TRIM56, an E3 ubiquitin ligase, as a key activator of the proto-oncogene Src in hepatocellular carcinoma.
Abel, S., Nguyen, M.D., and Theologis, A. (1995). The PS-IAA4/5-like family of early auxin-inducible mRNAs in Arabidopsis thaliana. J. Mol. Biol.251, 533-549 ...
Could overexpression of certain genes put women at a higher risk of Alzheimer’s disease? This seems to be the case for USP11, which partially evades silencing on one of the X chromosomes. This gene ...
p63, a member of the p53 family of transcription factors, plays an important role in epithelial development, regulating both cell cycle and apoptosis. Even though p63 activity is regulated mainly at ...
(b. 1976) B.S., 1997, Sichuan University; Ph.D., 2003, University of New Mexico; Postdoctoral Fellow, 2003-2007, Pennsylvania State University Our research program is at the interface of chemistry and ...
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