Good luck trying to predict what will happen during the 2025 NCAA Tournament. There are several talented teams capable of making deep runs through this year's bracket. Duke (ACC), Houston (Big 12), Michigan State (Big Ten) and St.

The top betting favorites as the tournament begins: Florida and Duke are listed as co-favorites (+325), according to BetMGM Sportsbook. Auburn (+425) and Houston (+600) are next. The Sweet 16 from March 27 to 30 will put games in Newark, New Jersey (East Regional), Atlanta (South), Indianapolis (Midwest) and San Francisco (West).

Sixteen games across the country Thursday opened up the first round of the 2025 NCAA Tournament and probably to some extent busted at least part of your March Madness bracket in the process. Maybe you picked High Point to take down Purdue or thought No.