Approved JAK inhibitors such as ruxolitinib and fedratinib target the JH1 kinase domain, offering symptomatic relief but lacking selectivity for the mutant form. This non-selective inhibition disrupts ...

A cohort study finds no significant differences in height among children with inflammatory diseases treated with JAK ...

"Lilly and Incyte to seek approval of alopecia JAK inhibitor in children" was originally created and published by Clinical Trials Arena, a GlobalData owned brand.

Abivax delivered outstanding phase 3 results for obefazimod in ulcerative colitis, with a 16.4% placebo-adjusted clinical ...

Results from the trial's first year were reported at the 2024 ACR meeting, and they persuaded the FDA to approve the drug for ...

A meta-analysis reveals that oral Janus kinase inhibitors elevate LDL and HDL cholesterol, underscoring the need for lipid monitoring in patients receiving JAK inhibitor therapy.

If you have rheumatoid arthritis (RA), your doctor may suggest Janus kinase (JAK) inhibitors to help ease your joint pain and swelling. These drugs tamp down your overactive immune system -- the ...

Scientists continue to discover treatments for atopic dermatitis, the most common form of the skin condition eczema. They’ve learned that JAK inhibitors, once reserved for other illnesses, also help ...

The F2 title contender made his practice debut at Mexico City. But with few F1 seats available, his wait may continue ...

The 20-year-old Texan will serve as reserve driver through 2026 after impressing in Formula 2 and free-practice sessions.

Aston Martin F1 junior Jak Crawford will step up to the role of third driver for the Silverstone squad for the 2026 season.