In this article, ACROBiosystems discusses how the complement cascade and it's various components could potentially be leveraged for therapeutic potential in COVID-19, cancer and general inflammation.

November 21, 2011 — The cartilage damage associated with osteoarthritis (OA) is in part a result of dysregulation of the complement system, Qian Wang, MD, PhD, and colleagues reported in an ...

To establish whether the effects of C1q on synapse elimination are mediated by the classical complement cascade, the authors examined another component of the cascade, C3. The expression of C3 in ...

After a slow start, the race is on to inhibit key proteins and pathways within the complement system -- a biological cascade that is central to the innate immune system and many different diseases ...

The complement system consists of a number of small proteins found in the blood, in general synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by ...

Researchers investigated the complement component 1q (C1q) binding and subsequent complement activation by neutralizing antibodies (nAbs) produced following COVID-19 vaccination.

Complement Therapeutics (CTx) is a Germany-based preclinical stage biotechnology company focusing on the R&D of novel therapeutic approaches to address unmet needs in disorders that affect the body’s ...

These potential medicines targeted the dysregulated cascade to potentially prevent further damage to healthy cells. However, tackling the complexities of complement biology was no small feat.

When C1q, the initiating factor of the complement cascade, was eliminated from these animals—either via genetic deletion or with antibody blocking—the researchers noted that synapses in the ...

In view of the importance of complement system in the initiation, regulation and end effects of immune responses and understanding of immune system as one of the targets for the toxic effects of ...

The end result of this complement activation or complement fixation cascade is stimulation of phagocytes to clear foreign and damaged material, proxy inflammation to attract additional phagocytes, and ...