Covalent modification of the oncogene product Mdm2 by the ubiquitin-related protein SUMO1 protects it from ubiquitination and enhances its E3 ligase activity towards p53 in vitro. Disappearance of ...

2004, MacDonald et al., 2004). More recently, we have sought to determine the biochemical mechanisms by which E3 ligases mediate ubiquitination of their substrates (Wang et al., 2004, Ungermannova et ...

who found a way to effectively label the ubiquitinated targets of a given E3 ligase with biotin directly inside cells. This allows the targets to be identified later using a technique called ...

While the TBM binds to a protein target, the URM is ubiquitinated and induces degradation of the protein target (Fig. 1). “SPiDEM is expanding the landscape of E3 ubiquitin ligases. The chemical ...

Co. Ltd. has identified proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase binding moiety coupled to an androgen receptor targeting moiety through a linker acting as androgen ...

He discovered a mechanism to efficiently identify the ubiquitinated targets of a particular E3 ligase with biotin inside of ...

We have taken a genomic approach to identify flower related Ubiquitin Proteasome System components from the RING type ubiquitin E3 ligase protein family. The Arabidopsis RING E3 ligases were retrieved ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

However, the power of PROTACs lies in the engagement of E3 ligases, and currently, less than two percent of the vast array of E3 ligases in the human genome have been explored in the TPD field. Dr.

DUNDEE, Scotland, Jan. 13, 2025 /PRNewswire/ -- Outrun Therapeutics ("Outrun"), the E3 ligase inhibitor and protein stabilisation specialist, today announces the appointment of Matthew Fyfe as its ...