Successful research in targeted protein degradation depends not only on measurements at high sensitivity, speed and precision ...

Investigators found that an E3 ligase FBXO22 could effectively mediate ... will continue to explore the use of TPD in different types of cancer. "We can use this method to continue to discover ...

However, the power of PROTACs lies in the engagement of E3 ligases, and currently, less than two percent of the vast array of E3 ligases in the human genome have been explored in the TPD field. Dr.

Covalent modification of the oncogene product Mdm2 by the ubiquitin-related protein SUMO1 protects it from ubiquitination and enhances its E3 ligase activity towards p53 in vitro. Disappearance of ...

Researchers from the Bhogaraju Group at EMBL Grenoble have developed a new method to study a critical type of protein ... a group of enzymes called E3 ubiquitin ligases attach a small protein ...