FOSTER CITY, Calif.--(BUSINESS WIRE)-- Gilead Sciences, Inc. (Nasdaq: GILD) today announced new data from a post-hoc analysis from the Phase 3 TROPiCS-02 study evaluating Trodelvy® (sacituzumab ...
Background Endometrial cancer is the most common gynecologic malignancy in developed countries. Trop-2 is a glycoprotein involved in cellular signal transduction and is differentially overexpressed ...
-BHV-1510 is a novel trophoblast cell surface antigen-2 (Trop-2) directed antibody drug conjugate (ADC) that has demonstrated a highly differentiated preclinical monotherapy efficacy profile, the ...
Here, we defined the Trop-2 expression profile in normal human tissues at the mRNA and protein levels. We then systematically compared Trop-2 expression in tumours with that in their normal tissues of ...
Is there a correlation between estrogen receptor expression level and early breast cancer survival? A retrospective study. This is an ASCO Meeting Abstract from the 2024 ASCO Annual Meeting I. This ...
First results from a randomized phase II study of cabazitaxel (CBZ) versus an androgen receptor targeted agent (ARTA) in patients with poor-prognosis castration-resistant prostate cancer (mCRPC). This ...
The main market opportunities in TROP-2-targeted immunotherapies lie in expanding applications beyond breast and bladder cancers, leveraging clinical validations by Trodelvy and Datroway. Ongoing ...
Antibody drug conjugate (ADC) research involves more and more targets, such as HER-2, Trop-2, Claudin-18.2, B7-H3 and B7-H4, etc. Trop-2 is a transmembrane glycoprotein. Its high expression is ...
Oncotarget recently published "Predictive biomarkers for sacituzumab govitecan efficacy in Trop-2-expressing triple-negative breast cancer" which reported that the authors investigated whether ...
Researchers from Duality Biologics (Suzhou) Co. Ltd. presented preclinical data for a novel Trop-2-targeting antibody-drug conjugate (ADC), DB-1305, being developed for the treatment of solid tumors.
*Because of the small number of events (deaths and progressions) in the G1 EEC category, the confidence interval was not reliable.
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