Living cells are fundamentally nonequilibrium systems, meaning they constantly spend energy through seemingly one-way, irreversible processes, such as transcribing DNA into RNA, to keep life going.

When the molecular machinery in our cells gets to work transcribing the genetic information encoded in DNA into messenger RNA (mRNA), it pauses shortly after starting. Known as promoter-proximal ...

Researchers from Children's Hospital of Philadelphia (CHOP) developed a new RNA sequencing strategy that can reveal how genetic variants disrupt gene function and improve the diagnosis of rare ...

A principle of DNA synthesis that has dominated biology textbooks for decades could be upended. An enzyme has been discovered ...

Researchers from Children's Hospital of Philadelphia (CHOP) developed a new RNA sequencing strategy that can reveal how ...

Researchers developed STRIPE, a targeted long-read RNA sequencing tool that identifies disease-causing variants missed by ...