Shortly after this Review was completed, we were saddened to learn that Dr Tao-shih Hsieh, of Duke University, Durham, North Carolina, USA, and Academia Sinica, Taipei, passed away. Hsieh was a true ...

This is a preview. Log in through your library . Abstract DNA topoisomerase II completely removes DNA intertwining, or catenation, between sister chromatids before they are segregated during cell ...

Women can be identified as being at increased risk for recurrence after primary surgery for breast cancer by a variety of pathologic factors including number of axillary lymph nodes involved with ...

Topoisomerase II is a key player in both the etiology and treatment of many cancers, including both primary and metastatic diseases. Normally, Topo II creates a transient gate in a DNA duplex by ...

This is a preview. Log in through your library . Abstract Topoisomerases type I and type II are enzymes that unwind and wind DNA, in order to control the synthesis of proteins. Therefore, targeting ...

Hormonal treatment of endometrial stromal sarcomas (ESS): A possible indication for aromatase inhibitors No standard treatment is established for patients with advanced soft tissue sarcoma after ...