T cells use distinct genetic programs to direct the development of distinct lineage subsets and the generation of an array of effector functions. T cells are instructed to use these developmental and ...

T cells are a critical part of the adaptive immune system that respond to pathogens, tumors, or play a key role in autoimmune diseases. A T cell recognizes potential targets through its T cell ...

Deck Bio, a biotechnology company advancing multi-pMHC targeted T cell engagers for solid tumors, today announced its participation in the 8th T-Cell Engager Therapeutics Summit and the BIO ...

Researchers have harnessed the power of artificial intelligence to tackle one of the most complex challenges in immunology: predicting how T cells recognize and respond to specific peptide antigens.

Immunotherapy has revolutionized cancer treatment by harnessing the power of T cells to attack tumors. But, even when these treatments are successful, scientists often struggle to understand exactly ...

Imagine your immune cells could be modified to attack any kind of cancer. T cell receptor (TCR) therapy has the potential to one day become a universal cancer treatment. But there are risks. Cells ...

Until now, the ability of T lymphocytes to distinguish between healthy and infected cells was deemed to be near perfect. New research findings published in eLife show this is not the case. T ...

Peptide-MHC complexes (pMHCs) are central to essential immune decisions, including recognition of infection, autoimmune and tumor eradication. After thymic selection, T cell receptors (TCRs) are the ...

New designer proteins created using an AI tool can selectively target peptide segments that bind to markers on diseased cancer cells, acting like molecular flags that signal immune cells to attack and ...