San Francisco 49ers wide receiver Ricky Pearsall is dealing with multiple injury concerns following Week 15’s win vs. the Titans.

San Francisco 49ers quarterback Brock Purdy (13) runs the ball past Tennessee Titans linebacker Cedric Gray, left, during the second half of an NFL football game, Sunday, Dec. 14, 2025, in Santa Clara, Calif. Credit: AP/Godofredo A. Vásquez

Titans PFF grades reveal the best and worst performers, key snap counts, and standout moments from San Francisco's Week 15 win.

The 49ers are just one game back of the NFC-leading Los Angeles Rams (11-3) for the conference’s No. 1 playoff seed, but Los Angeles plays the Seattle Seahawks — also 11-3 — in Week 16, so San Francisco won’t be able to claim the top seed in Week 16 since one of those two teams still will have a better record at the end of the week.

It helps when George Kittle, Jauan Jennings, and Ricky Pearsall all seem to be healthy and at their best. Still, there is no denying that Purdy was looking at his healthiest as well, and he was making plays just as much as anyone in this win.

Which team will win the NFL Week 16 game on Monday Night Football? Check out these NFL Week 16 picks and NFL Week 16 predictions for the game, which can be seen at 6:15 p.m. MST on ESPN (stream with FUBO).

San Francisco 49ers coach Kyle Shanahan has shared some concerning news following the team's win over the Tennessee Titans.

Two defensive stars were lost for the season. Their QB missed multiple games. Still, here are the 49ers are, a game out of the No. 1 seed.