Nature

Rho GTPase Signaling in Cancer Cell Dynamics

Rho GTPases constitute a family of molecular switches that orchestrate the remodelling of the actin cytoskeleton, thereby directing cell shape, adhesion, migration and invasion. In their active ...
Nature

Rho GTPase Signaling in Apoptosis and Cell Motility

Rho GTPases are small molecular switches that coordinate the dynamic reorganisation of the actin cytoskeleton to drive cell motility and to regulate programmed cell death. Members of the family such ...
EurekAlert!

Functionally redundant Rho GTPases Cdc42 and RacA regulate aflatoxin synthesis and pathogenicity in Aspergillus flavus by controlling morphogenesis, oxidative balance and ...

Rho GTPases Cdc42 and RacA share significant sequence homology and are conserved among eukaryotic species. These proteins act as molecular switches in various signal transduction pathways by cycling ...
GEN

Chemical Genetics Shows How “Undruggable” GTPases Can Be Targeted

Scientists at the University of California, San Francisco (UCSF), have discovered how to target a class of molecular switches called GTPases that are involved in a myriad of diseases—from Parkinson’s ...
ascopubs.org

Frequent mutations of genes predisposing to Rho GTPase signal activation and autophagy inhibition in metastatic soft tissue sarcoma unveiled by paired somatic and germline ...

Results of the dose-finding phase of ARST 1321 from the Children's Oncology Group and NRG Oncology: Neoadjuvant chemoradiation or radiation therapy +/- pazopanib in non-rhabdomyosarcoma soft tissue ...