Multiple layers of regulation modulate the ... USP44 deubiquitylates CDC20, a co-activator of the E3 ubiquitin ligase anaphase promoting complex or cyclosome (APC/C) that promotes the degradation ...

40 types), and a ubiquitin ligase (E3, over 600 types). This reaction is repeated to form ubiquitin chains. This study found that the ubiquitination that inactivates Nrf1 was performed by two E3s ...

In this study, we will establish the role of RING genes in fungal susceptibility using a RING gene knockout collection and Botrytis cinerea as model pathogen, through the high-throughput screening ...

We have selected the protein group of RING type ubiquitin E3 ligases to assign them in plant developmental stages and organs by gene expression profiles, by high throughput phenotyping of ...

These use E3 ubiquitin ligases to promote the degradation of ... targeting two neurodegenerative disorder targets, as well as multiple cancer targets, and an antiviral program.

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

These innovative compounds leverage the ubiquitin-proteasome system (UPS) to degrade challenging targets, providing new avenues for intervention beyond traditional small molecules. However, the power ...

Through its E-rich motif, VGLL3 associates with KLHL15, an E3 ubiquitin ligase adapter ... impairing the recruitment of ...

Professor Zoran Rankovic’s group is developing PROTACs, Molecular Glue Degraders, and E3 ubiquitin ligase chemical probes to study cancer biology and develop novel cancer drugs. Our group's research ...