Multiple sequence alignment (MSA) is a cornerstone of computational biology, facilitating the exploration of functional, structural and evolutionary relationships among biological sequences.

BLAST (Basic Local Alignment Search Tool): Helps identify homologous sequences by comparing a query sequence to a database. Clustal Omega: Performs multiple sequence alignments, essential for ...

Edgar calls his new algorithm MUSCLE (multiple sequence comparison by log expectation). MUSCLE uses a log expectation score to control progressive alignment of the input amino acid sequences. This ...