The dynamic interchange between monomeric G-actin and polymeric F-actin filaments is fundamental to cell motility and cytokinesis. Actin filament dynamics is regulated by numerous actin-binding ...

The design and synthesis of novel 15-membered 11-azalides and 16-membered 11,12-diazalide starting from 16-membered macrolides are reported. A mobile linear dialdehyde was isolated via a cyclic ...

Macrolides are an important class of antibiotics that includes drugs such as azithromycin and erythromycin, which are widely used to treat a range of infections, including pneumonia and skin ...

Researchers from North Carolina State University have created the largest publicly available virtual library of macrolide scaffolds. The library - called V1M - contains chemical structures and ...