The DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester ...

the 5’-OH of the distal half-molecule is phosphorylated by a kinase; and (iii) the 3’-OH,2’-PO 4 and 5’-PO 4 ends are sealed by an ATP-dependent RNA ligase to form a spliced tRNA with an ...

"We can use this method to continue to discover new ligases that can support small molecule induced protein degradation," Zhang said. "We will be very interested in further exploring these ligases ...

The company, a spin-out from the University of Dundee's MRC Protein Phosphorylation and Ubiquitylation Unit, is pioneering the development of small molecule drugs targeting E3 ligases. The ...

Through this platform, the Company has built a rich pipeline of highly valuable, first-in-class, small molecule E3 ligase inhibitors that prevent protein degradation, while identifying novel E3 ...

Figure 2: Ligation of circularizable probes by Ampligase, a thermostable DNA ligase. To facilitate allele ... events on a glass surface by single-molecule analysis. We prepared slides containing ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Through this platform, the Company has built a rich pipeline of highly valuable, first-in-class, small molecule E3 ligase inhibitors that prevent protein degradation, while identifying novel E3 ligase ...