To study the function and mechanism of bigelovin, a sesquiterpene lactone from the flower of Chinese herb Inula hupehensis, in regulating JAK2/STAT3 signaling and cancer cell growth. HepG2 cells ...

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) cascade is a signal transduction pathway that was originally identified in the vertebrate system 1, 2 and has been ...

New research indicates that drugs that target a cell growth pathway known as the JAK-STAT pathway are likely to be effective against certain chronic leukemias. Researchers recently discovered that a ...

Ischemic stroke is a major cause of death and disability, caused by a sudden loss of oxygen supply to the brain due to blocked blood vessels. Recanalization treatments such as intravenous thrombolysis ...

The JAK2 gene is a protein-coding gene of the Janus kinase family. It plays a role in cellular signaling. Evidence notes connections between this gene and some medical conditions. Variations in this ...

Cosmetic outcome after intraoperative radiotherapy or external beam radiotherapy for early breast cancer: An objective assessment of patients from a randomized controlled trial. Effect of adjuvant ...

Mechanisms of acquired afatinib resistance in HER2-positive breast cancer cells. This is an ASCO Meeting Abstract from the 2015 ASCO Annual Meeting I. This abstract does not include a full text ...

When malfunctions occur in the biological machinery our muscles or our brains use for renewal and repairs, these tissues ...

Eosinophilic cellulitis (EC) is a type 2 inflammatory disease that activates the JAK1/JAK2-STAT5 pathways, an analysis of skin biopsy specimens suggests. To better understand the pathogenesis of EC, ...

Explore the latest advances in alopecia areata treatment, including FDA-approved JAK inhibitors and promising topical ...

-Reported Lack of Blood and Platelet Side Effects Provides Attractive Regulatory and Commercial Profile over other JAK inhibitors, -Conference Call Scheduled, Today at 8:30 A.M. Eastern Time SEATTLE ...

Scientists at Children’s Hospital of Philadelphia (CHOP) say they have pinpointed a genetic variation responsible for driving the development of inflammatory bowel disease (IBD). The genetic pathway ...