As the attacks escalate, with fatalities and injuries reported on both sides, Israel issued the stark warning to Iran.

The Israel-Iran conflict has escalated into its fourth day with mounting casualties, widening attacks, and no sign of diplomatic resolution.

The conflict between Israel and Iran has forced many countries in the Middle East to close their airspace, as Israeli jets and Iranian exploding drones and missiles fly over their night skies.

Israel faced retaliation from Iran after launching missiles against Tehran's leadership and energy infrastructure as part of "Operation Rising Lion" this weekend. Iran's military responded with a wave of missile strikes against Israel,

Although Iran maintains that its nuclear program is for peaceful energy purposes, Israel has long seen it as a threat. Israeli strikes have hit three of Iran’s nuclear facilities — Natanz, Isfahan and Fordow. Little damage appears visible in satellite imagery of Fordow.

Israel warned Tehran civilians to evacuate the city ahead of planned Israeli strikes on “the Iranian regime’s military infrastructure” on Monday—the first time in the now four-day conflict that an evacuation warning has been issued for targeted residential areas.

President Trump rejected an Israeli plan in recent days to kill Iran's Supreme Leader Ayatollah Ali Khamenei, a senior U.S. official told USA TODAY.

Stocks are down on Friday, with oil prices surging in the wake of the Israel's military strike on Iran. The S&P 500 slid 48 points, or 0.5%, to 5,998 points in early trading, while the Dow Jones Industrial Average dropped 559 points,