The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused immense suffering and economic hardship to millions of people worldwide. To date, the mechanism of infection by SARS-CoV-2 ...

As the main surface receptors that connect cells to the extracellular matrix (ECM), integrins control cell adhesion and migration — the fundamental cell behaviours that underlie development, immune ...

The Fagerholm group studies the role of leukocyte integrins in various immune reactions. We are interested in the in vivo roles and regulation of leukocyte beta2-integrins in a healthy and ...

Integrins are major cell surface receptors for the extracellular matrix (ECM). Intracellularly, integrins link to the actin cytoskeleton and signalling systems and thus function as mechanochemical ...

In a recent study posted to the medRxiv* pre-print server, a team of researchers demonstrated the inhibitory action of integrin/transforming growth factor beta 1 (TGF-β1) inhibitor GLPG0187 on severe ...

Researchers from the US and China summarize the role of integrins in cancer cells and the current status of anti-integrin therapy for cancer Globally, human hepatocellular carcinoma (HCC) is the sixth ...

Protein evolution occurs slowly via small incremental mutations—usually. However, dramatic changes can happen: for instance, a fragment of one protein getting copied into the middle of another. While ...

Initial clinical experience with the first-in-class anti-metastasis therapeutic TTX-MC138. A phase 1 study of LB4330, a peptide fused to CLDN18.2 antibody targeting the tumor antigen associated (TAA) ...